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WDSD Fundraiser

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Raising funds for Down syndrome research on
World Down Syndrome Day 

Recognizing the global impact of research, since 2010, Alexander's Angels decided that funds raised during World Down Syndrome Day celebrations be donated to Down syndrome research. 

These two organizations have been chosen to be our beneficiaries this year.  This is what they do:

Lu-Mind Research Down Syndrome Foundation http://www.lumindrds.org  
With a mission to stimulate biomedical research that will accelerate the development of treatments to significantly improve cognition, including memory, learning and speech for individuals with Down syndrome so they participate more successfully in school and employment, lead more active and independent lives, and avoid the early cognitive decline with aging and Alzheimer's Disease.  LuMind RDS Foundation has awarded more than $15 million in research grants since their founding in 2004.  Alexander's Angels has supported their research efforts since $2007 by donating over $200,000.  Let's continue to be part of the exciting journey to improve the level of cognition of individuals with Down syndrome!
 
Dr. Xiao-Fei Kong's research at the Rockefeller University 
Dr.Kong's research at the Rockefeller University demonstrated that the three copies of interferon receptor genes affect the interferon systems through the increased expression of receptors as well as the enhanced interferon responses of immune cells. The overacting interferon system is well known to be related to autoimmune diseases, including lupus, thyroid disorders, type I diabetes mellitus, diseases common in Down syndrome.  Dr. Kong's study also found that about 10% of individuals with Down syndrome have skin candidiasis, a type of fungal infection. He searched for the evidence to support the hypothesis that the susceptibility of individuals with Down syndrome to fungal infection is due to an impaired T cells immunity from overacting interferon system. He found some clues of aberrant T cells in individuals with Down syndrome with more steps to clench the study. 

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